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• CONTRACEPTIVE DIANE 35 ACNE SKIN

4, 5 Warnings to minimize a woman's exposure to the drug result in part from the association with venous thromboembolic disease.

CONTRACEPTIVE DIANE 35 ACNE SKIN

4 Treatment with Diane-35 should be discontinued 3–4 menstrual cycles after a woman's skin condition has resolved. 4 Cyproterone acetate has anti-androgen effects resulting in part from its blockade of androgen receptors, and Diane-35 is approved only as therapy for androgen-sensitive skin conditions, including hirsutism and severe acne unresponsive to oral antibiotic therapy.

The drug: Diane-35, which contains ethinylestradiol (35 μg) and cyproterone acetate (2 mg), provides effective birth control but is not indicated as such.

4 The UK Committee on the Safety of Medicines recently issued a warning on the drug's risk of venous thromboembolism, 5 which was repeated verbatim by Health Canada in late December 2002. 2 However, many physicians may be unaware of concerns about the drug's safety profile 3 and the fact that it is not approved for use solely as an oral contraceptive. Reason for posting: Diane-35, an oral contraceptive with anti-androgen properties, has been heavily marketed to young women 1 and has seen its Canadian sales jump by 45% between 20 alone.